Article

Transcriptional and mutational signatures of the aging germline

2021-11-22

Abstract excerpt

Aging is a complex biological process that is accompanied by changes in gene expression and mutational load. In many species, including humans, older fathers pass on more paternally-derived de novo mutations; however, the cellular basis and cell types driving this pattern are still unclear. To explore the root causes of this phenomenon, we performed single-cell RNA-sequencing (scRNA-seq) on testes from young and...

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Literature Corpus work: 5d947ae4-0aab-5cff-81a2-fac851040629
DOI: 10.1101/2021.11.22.469565

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