Article

Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes

2018-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Mosaic mutations present in the germline have important implications for reproductive risk and disease transmission. We previously demonstrated a phenomenon occurring in the male germline, whereby specific mutations arising spontaneously in stem cells (spermatogonia) lead to clonal expansion, resulting in elevated mutation levels in sperm over time. This process, termed selfish spermatogonial s...

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Literature Corpus work: 19a70a33-e3fb-5260-9036-9c3c7677798d
DOI: 10.1101/314815

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