Article

Multitargeted Reduction of Inflammation and Atherosclerosis in <i>Tet2</i> -deficient CHIP via XPO1 Inhibition and Atf3 restoration

2025-06-17

Abstract excerpt

<h4>ABSTRACT</h4> TET2 is the second most frequently mutated gene in clonal hematopoiesis of indeterminate potential (CHIP), driving hematopoietic stem cell clonal expansion and increasing the risk of myeloid malignancies. Affected individuals often develop atherosclerotic cardiovascular disease, exacerbated by hyperinflammatory TET2 -mutant macrophages. Here, we show that the XPO1 nuclear export inhibitor eltan...

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Literature Corpus work: 0280af8a-b3d5-549c-afde-643b27a83d68
DOI: 10.1101/2025.06.12.658927

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