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Article

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

The New England journal of medicine - 13 Jul 2017

Jaiswal Siddhartha, Natarajan Pradeep, Silver Alexander J, Gibson Christopher J, Bick Alexander G, Shvartz Eugenia, McConkey Marie, Gupta Namrata, Gabriel Stacey, Ardissino Diego, Baber Usman, Mehran Roxana, Fuster Valentin, Danesh John, Frossard Philippe, Saleheen Danish, Melander Olle, Sukhova Galina K, Neuberg Donna, Libby Peter, Kathiresan Sekar, Ebert Benjamin L

Abstract excerpt

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer. We previously found preliminary evidence for an association between CHIP and atherosclerotic cardiovascular disease, but the...

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Identifiers

PMID: 28636844
DOI: 10.1056/NEJMoa1701719
PMCID: PMC6717509

Genes

ASXL1
JAK2
TET2

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