Article

Non-preferential, but detrimental accumulation of macrophages with clonal hematopoiesis-driver mutations in cardiovascular tissues

2023-09-15

Abstract excerpt

<h4>Summary</h4> Clonal hematopoiesis of indeterminate potential (CHIP) is an acquired genetic risk factor for cardiovascular (CV) disease, supposedly mediated by pro-inflammatory recruited monocytes 1–15 . However, how these cells and their progeny behave in the CV tissue remains unclear. Here, we studied human carotid artery plaque and heart tissue samples from DNMT3A or TET2 mutation carriers to quantify th...

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Literature Corpus work: 6a64ab96-3554-52b7-ae31-b103515d7cf8
DOI: 10.1101/2023.09.11.557290

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