Article

Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms

2021-06-11

Abstract excerpt

<h4>Background</h4> Genome-wide association studies of prostate cancer have identified >250 significant risk loci, but the causal variants and mechanisms for these loci remain largely unknown. Here, we sought to identify and characterize risk harboring regulatory elements by integrating epigenomes from primary prostate tumor and normal tissues of 27 patients across the H3K27ac, H3K4me3, and H3K4me2 histone marks...

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Literature Corpus work: 0261228b-e028-5ec6-97e7-6d85786cb33b
DOI: 10.1101/2021.06.02.446619

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