Article

Structural basis for EROS binding to human phagocyte NADPH oxidase NOX2

2023-09-11

Abstract excerpt

<h4>ABSTRACT</h4> EROS (essential for reactive oxygen species) is a recently identified molecular chaperone of NOX2 (gp91 phox ), the catalytic subunit of phagocyte NADPH oxidase. Deficiency in NOX2 expression or function due to genetic mutations leads to chronic granulomatous disease (CGD) with recurrent bacterial and fungal infections. To delineate how EROS interacts with NOX2, we solved the cryo-EM structure...

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Literature Corpus work: 025be973-ad3c-5761-8002-446097f4f6a7
DOI: 10.1101/2023.09.11.557130

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