Article

<i>EROS</i> is required for phagocyte NADPH oxidase function in humans and its deficiency causes Chronic Granulomatous Disease

2018-05-28

Abstract excerpt

The phagocyte respiratory burst is mediated by the phagocyte NADPH oxidase, a multi-protein subunit complex that facilitates production of reactive oxygen species and which is essential for host defence. Monogenic deficiency of individual subunits leads to chronic granulomatous disease (CGD), which is characterized by an inability to make reactive oxygen species, leading to severe opportunistic infections and auto...

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Literature Corpus work: 7d725624-ac5e-59e7-9b3a-6446f5f908aa
DOI: 10.1101/331454

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