Article

Structural Mechanism of Electron Shuttling in Inducible Nitric Oxide Synthase

2026-04-19

Abstract excerpt

Nitric oxide (NO) signaling is pivotal in numerous physiological processes and is implicated in a spectrum of human diseases. Nitric oxide synthases (NOS) initiate NO signaling and govern its magnitude and duration, making them key drug targets. Despite decades of investigation, the structural mechanism by which NOS enzymes transfer electrons from NADPH to haem remains incompletely understood. Here, we report cryo...

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Literature Corpus work: 06258b06-b24b-5f71-b14b-4c3223f1de9a
DOI: 10.64898/2026.04.17.719136

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Structural Mechanism of Electron Shuttling in Inducible Nitric Oxide SynthaseDOI 10.64898/2026.04.17.719136Read

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