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Article

NADPH oxidase 4 function as a hydrogen peroxide sensor.

Journal of biochemistry - 1 Jun 2018

Nisimoto Yukio, Ogawa Hisamitsu, Kadokawa Yuzo, Qiao Shanlou

Abstract excerpt

Nox4, a member of the NADPH- and oxygen-dependent oxidoreductases that generate reactive oxygen species (ROS), is widely expressed and constitutively active. To understand better its function and regulation, specific mutations in the Nox4 dehydrogenase (DH) domain were examined for effects on Nox4 oxidase activity. Transfection of His6-tagged Nox4 increased the amount of p22phox subunit in HEK293 cells, and a...

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PMID: 29365138
DOI: 10.1093/jb/mvy014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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