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Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst

21 Jul 2015

Abstract excerpt

The phagocyte oxidative burst, mediated by Nox2 NADPH oxidase-derived reactive oxygen species, confers host defense against a broad spectrum of bacterial and fungal pathogens. Loss-of-function mutations that impair function of the Nox2 complex result in a life-threatening immunodeficiency, and genetic variants of Nox2 subunits have been implicated in pathogenesis of inflammatory bowel disease (IBD). Thus,...

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PMID: 26194095
DOI: 10.1038/ncomms8838

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