Article
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4.
The Journal of biological chemistry - 15 Apr 2011
Takac Ina, Schröder Katrin, Zhang Leilei, Lardy Bernard, Anilkumar Narayana, Lambeth J David, Shah Ajay M, Morel Francoise, Brandes Ralf P
Abstract excerpt
In contrast to the NADPH oxidases Nox1 and Nox2, which generate superoxide (O(2)(·-)), Nox4 produces hydrogen peroxide (H(2)O(2)). We constructed chimeric proteins and mutants to address the protein region that specifies which reactive oxygen species is produced. Reactive oxygen species were measured with luminol/horseradish peroxidase and Amplex Red for H(2)O(2) versus L-012 and cytochrome c for O(2)(·-). The...
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