Article
Cancer and the bromodomains of BAF180.
Biochemical Society transactions - 1 Apr 2012
Brownlee Peter M, Chambers Anna L, Oliver Antony W, Downs Jessica A
Abstract excerpt
Chromatin remodelling complexes alter the structure of chromatin and have central roles in all DNA-templated activities, including regulation of gene expression and DNA repair. Mutations in subunits of the PBAF (polybromo/Brg1-associated factor) or SWI/SNF-B remodelling complex, including BAF180, are frequently associated with cancer. There are six potential acetyl-lysine-binding BDs (bromodomains) in BAF180,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
