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Overlapping coactivator function is required for transcriptional activation by the <i>Candida glabrata</i> Pdr1 transcription factor

2024-05-30

Abstract excerpt

Azole resistance in the pathogenic yeast Candida glabrata is a serious clinical complication and increasing in frequency. The majority of resistant organisms have been found to contain a substitution mutation in the Zn2Cys6 zinc cluster-containing transcription factor Pdr1. These mutations typically lead to this factor driving high, constitutive expression of target genes like the ATP-binding cassette transporter...

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Literature Corpus work
0252a4c8-624b-5f09-93b6-4ed26b596cdc
DOI
10.1101/2024.05.24.595833
Open publication

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Overlapping coactivator function is required for transcriptional activation by the <i>Candida glabrata</i> Pdr1 transcription factorDOI 10.1101/2024.05.24.595833
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