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Article

Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata

4 Dec 2010

Abstract excerpt

Candida glabrata is an opportunistic human pathogen that is increasingly associated with candidemia, owing in part to the intrinsic and acquired high tolerance the organism exhibits for the important clinical antifungal drug fluconazole. This elevated fluconazole resistance often develops through gain-of-function mutations in the zinc cluster-containing transcriptional regulator C. glabrata Pdr1 (CgPdr1). CgPdr1...

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PMID: 21131438
DOI: 10.1128/ec.00277-10

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