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Article

Calcineurin is required for Candida glabrata Pdr1 transcriptional activation

9 Nov 2023

Abstract excerpt

ABSTRACT Fluconazole is one of the most commonly used antifungals today. A result of this has been the inevitable selection of fluconazole-resistant organisms. This is an especially acute problem in the pathogenic yeast Candida glabrata . Elevated minimal inhibitory concentrations for fluconazole in C. glabrata are frequently associated with substitution mutations within the Zn2Cys6 zinc cluster-containing...

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PMID: 37943042
DOI: 10.1128/mbio.02416-23

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