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Article

Genomewide Expression Profile Analysis of the Candida glabrata Pdr1 Regulon

31 Dec 2010

Abstract excerpt

The ABC transporters Candida glabrata Cdr1 (CgCdr1), CgPdh1, and CgSnq2 are known to mediate azole resistance in the pathogenic fungus C. glabrata. Activating mutations in CgPDR1, a zinc cluster transcription factor, result in constitutive upregulation of these ABC transporter genes but to various degrees. We examined the genomewide gene expression profiles of two matched azole-susceptible and -resistant C....

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PMID: 21193550
DOI: 10.1128/ec.00073-10

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