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Article

Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor

24 Jan 2018

Abstract excerpt

Resistance to azole drugs, the major clinical antifungal compounds, is most commonly due to gain-of-function (GOF) substitution mutations in a gene called PDR1 in the fungal pathogen Candida glabrata. PDR1 encodes a zinc cluster-containing transcription factor. GOF forms of Pdr1 drive high level expression of downstream target gene expression with accompanying azole resistance. PDR1 has two homologous genes in...

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PMID: 29363861
DOI: 10.1111/mmi.13913

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