Article

The Proper Interplay Between the Expression of Spo11 Splice Isoforms and the Structure of the Pseudoautosomal Region Promotes Xy Chromosomes Recombination

2023-08-09

Abstract excerpt

XY chromosome missegregation is relatively common in humans and can lead to sterility or the generation of aneuploid spermatozoa. A leading cause of XY missegregation in mammals is the lack of formation of double-strand breaks (DSBs) in the pseudo-autosomal region (PAR), a defect that may occur in mice due to faulty expression of Spo11 splice isoforms. Using a knock-in (ki) mouse that expresses only the single Spo...

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Literature Corpus work: 022ebcb9-67a0-59ab-ac6d-3eb9bcfba71f
DOI: 10.21203/rs.3.rs-3235584/v1

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