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Article

Meiotic recombination: breaking the genome to save it.

Current biology : CB - 3 Apr 2001

Lichten M

Abstract excerpt

Recombination ensures the correct segregation of chromosomes to gametes during meiosis. Recent studies point to a universal mechanism for initiating meiotic recombination: the formation of double-strand DNA breaks by Spo11p.

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Identifiers

PMID: 11413012
DOI: 10.1016/s0960-9822(01)00131-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Meiotic recombination: breaking the genome to save it.PMID 11413012Read ↗

Spo11: from topoisomerase VI to meiotic recombination initiatorSemantic proximity Read ↗

Mechanism and control of meiotic recombination initiation.Semantic proximity Read ↗

mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: evidence that the mechanism for initiating meiotic recombination is conserved.Semantic proximity Read ↗

Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe.Semantic proximity Read ↗

Both conserved and non-conserved regions of Spo11 are essential for meiotic recombination initiation in yeast.Semantic proximity Read ↗

The multiple roles of the Mre11 complex for meiotic recombination.Semantic proximity Read ↗

Support for a meiotic recombination initiation complex: interactions among Rec102p, Rec104p, and Spo11p.Semantic proximity Read ↗

A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae.Semantic proximity Read ↗

Genome wide analysis of meiotic recombination in yeast: For a few SNPs more.Semantic proximity Read ↗

A DNA topoisomerase VI–like complex initiates meiotic recombinationSemantic proximity Read ↗

DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosisSemantic proximity Read ↗

Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis.Semantic proximity Read ↗

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