Article
Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele.
BMC genomics - 22 Jul 2013
Smagulova Fatima, Brick Kevin, Pu Yongmei, Sengupta Uttara, Camerini-Otero R Daniel, Petukhova Galina V
Abstract excerpt
BACKGROUND: Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA binding specificity of the PRDM9 protein in human, mice and most other mammals. In budding yeast...
Topics
- Alleles
- Animals
- Binding Sites
- Chromosome Pairing
- Cluster Analysis
- DNA Breaks, Double-Stranded
- Endodeoxyribonucleases
- Gene Knock-In Techniques
- Genomics
- Mice
- Recombination, Genetic
- Telomere