Article
Proteasome activator PA200 is required for normal spermatogenesis.
Molecular and cellular biology - 1 Apr 2006
Khor Bernard, Bredemeyer Andrea L, Huang Ching-Yu, Turnbull Isaiah R, Evans Ryan, Maggi Leonard B, White J Michael, Walker Laura M, Carnes Kay, Hess Rex A, Sleckman Barry P
Abstract excerpt
The PA200 proteasome activator is a broadly expressed nuclear protein. Although how PA200 normally functions is not fully understood, it has been suggested to be involved in the repair of DNA double-strand breaks (DSBs). The PA200 gene (Psme4) is composed of 45 coding exons spanning 108 kb on mouse chromosome 11. We generated a PA200 null allele (PA200(Delta)) through Cre-loxP-mediated interchromosomal...
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