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Article

The proper interplay between the expression of Spo11 splice isoforms and the structure of the pseudoautosomal region promotes XY chromosomes recombination.

Cellular and molecular life sciences : CMLS - 8 Sept 2023

Giannattasio Teresa, Testa Erika, Faieta Monica, Lampitto Matteo, Nardozi Daniela, di Cecca Stefano, Russo Antonella, Barchi Marco

Abstract excerpt

XY chromosome missegregation is relatively common in humans and can lead to sterility or the generation of aneuploid spermatozoa. A leading cause of XY missegregation in mammals is the lack of formation of double-strand breaks (DSBs) in the pseudoautosomal region (PAR), a defect that may occur in mice due to faulty expression of Spo11 splice isoforms. Using a knock-in (ki) mouse that expresses only the single...

Topics

Animals
Humans
Male
Mice
Alleles
Protein Isoforms
Pseudoautosomal Regions
Recombination, Genetic
Semen
Endodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37682311
DOI: 10.1007/s00018-023-04912-7
PMCID: PMC10491539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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