Article

Methionine dependence in cancer cells due to lack of B <sub>12</sub> -dependent methionine synthase activity

2025-02-27

Abstract excerpt

Human cells can synthesize methionine from homocysteine and folate-coupled methyl groups via the B 12 -dependent enzyme methionine synthase (MTR). Yet, it has been known for decades that cancer cells fail to grow when methionine is replaced by homocysteine, a phenomenon known as methionine dependence. The underlying mechanism remains unknown. Here, we report evidence that methionine dependence is caused by low MT...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 021a918a-ba7f-5d99-974a-bcf405c57df8
DOI: 10.1101/2025.02.27.640554

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Methionine dependence in cancer cells due to lack of B <sub>12</sub> -dependent methionine synthase activityDOI 10.1101/2025.02.27.640554Read

The role of B12 deficiency and methionine synthase in methionine-dependent cancer cellsSemantic proximity Read

Methionine dependency of malignant tumors: a possible approach for therapy.Semantic proximity Read

Methionine synthase supports tumour tetrahydrofolate pools.Semantic proximity Read

Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells.Semantic proximity Read

Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer.Semantic proximity Read

Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence.Semantic proximity Read

Linking vitamin B1 with cancer cell metabolismSemantic proximity Read

A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension.Semantic proximity Read

Methionine Restriction Reduces Lung Cancer Progression and Increases Chemotherapy ResponseSemantic proximity Read

Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).Semantic proximity Read

Methionine restriction for cancer therapy: A comprehensive review of mechanisms and clinical applicationsSemantic proximity Read

Methionine Metabolism Controls the B-cell EBV Epigenome and Viral LatencySemantic proximity Read