Article
Methionine synthase supports tumour tetrahydrofolate pools.
Nature metabolism - 1 Nov 2021
Ghergurovich Jonathan M, Xu Xincheng, Wang Joshua Z, Yang Lifeng, Ryseck Rolf-Peter, Wang Lin, Rabinowitz Joshua D
Abstract excerpt
Mammalian cells require activated folates to generate nucleotides for growth and division. The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR). Cobalamin deficiency traps folates as 5-methyl-THF. Here, we show using isotope tracing that MTR is only a minor...
Topics
- 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- Cell Line, Tumor
- Cell Proliferation
- Folic Acid
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Humans
- Metabolic Networks and Pathways
- Methionine
- Methylation
- Mutation
- Neoplasms
- Purines