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Article

Methionine synthase supports tumour tetrahydrofolate pools.

Nature metabolism - 1 Nov 2021

Ghergurovich Jonathan M, Xu Xincheng, Wang Joshua Z, Yang Lifeng, Ryseck Rolf-Peter, Wang Lin, Rabinowitz Joshua D

Abstract excerpt

Mammalian cells require activated folates to generate nucleotides for growth and division. The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR). Cobalamin deficiency traps folates as 5-methyl-THF. Here, we show using isotope tracing that MTR is only a minor...

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Identifiers

PMID: 34799699
DOI: 10.1038/s42255-021-00465-w
PMCID: PMC9284419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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