Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence.

doi:10.1016/j.ymgme.2008.12.011

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Article

Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence.

Molecular genetics and metabolism - 1 Apr 2009

Loewy Amanda D, Niles Kirsten M, Anastasio Natascia, Watkins David, Lavoie Josée, Lerner-Ellis Jordan P, Pastinen Tomi, Trasler Jacquetta M, Rosenblatt David S

Abstract excerpt

Methionine dependence, the inability of cells to grow when the amino acid methionine is replaced in culture medium by its metabolic precursor homocysteine, is characteristic of many cancer cell lines and some tumors in situ. Most cell lines proliferate normally under these conditions. The methionine dependent tumorigenic human melanoma cell line MeWo-LC1 was derived from the methionine independent non-tumorigenic...

Topics

Alleles
Carrier Proteins
Cell Line, Tumor
Cell Proliferation
CpG Islands
DNA Methylation
DNA, Complementary
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methionine

Molecular Chaperones

Neoplasm Proteins

Neoplasms

Oxidoreductases

Transfection

Vitamin B 12

Source

Open in PubMed

Identifiers

PMID: 19200761
DOI: 10.1016/j.ymgme.2008.12.011

Genes

MMACHC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Epigenetic modification of the gene for the vitamin B(12) chaperone MMACHC can result in increased tumorigenicity and methionine dependence.PMID 19200761Read ↗

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