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Article

Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells.

Journal of cellular physiology - 1 Nov 1991

Liteplo R G, Hipwell S E, Rosenblatt D S, Sillaots S, Lue-Shing H

Abstract excerpt

Our aim was to identify the biochemical defect responsible for the inability of highly growth autonomous human tumor cells to proliferate in culture medium devoid of methionine, but containing homocysteine and 5-methyletrahydrofolic acid. We have adopted the terms "homocysteine-responsive" and "homocysteine-nonresponsive" to describe cells which can or cannot proliferate in methionine-free...

Topics

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Cell Division
Homocysteine
Humans
Melanoma
Methionine
Phenotype
Tetrahydrofolates
Tumor Cells, Cultured
Vitamin B 12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1748723
DOI: 10.1002/jcp.1041490222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1748723-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Changes in cobalamin metabolism are associated with the altered methionine auxotrophy of highly growth autonomous human melanoma cells.PMID 1748723Read ↗

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