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The role of B12 deficiency and methionine synthase in methionine-dependent cancer cells

2 Jul 2025

Abstract excerpt

Abstract Background Human cells can synthesize methionine from homocysteine and folate-coupled methyl groups via the B12-dependent enzyme methionine synthase (MTR). Yet, it has been known for decades that cancer cells fail to grow when methionine is replaced by homocysteine, a phenomenon known as methionine dependence. The underlying mechanism remains unknown. Methods Cancer cell lines were cultured with...

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PMID: 40605016
DOI: 10.1186/s40170-025-00405-2

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