Article
Methionine dependency of malignant tumors: a possible approach for therapy.
Journal of the National Cancer Institute - 17 Oct 1990
Breillout F, Antoine E, Poupon M F
Abstract excerpt
When methionine (Met), an essential amino acid, was substituted for by its precursor homocysteine (Hcy) in the culture medium, normal cells such as fibroblasts proliferated normally. In contrast, many tumor cells failed to grow or grew at a lower rate. Met dependency is acquired simultaneously wi...
Topics
- Adenocarcinoma
- Animals
- Breast Neoplasms
- Cell Movement
- Colonic Neoplasms
- Culture Media
- Female
- Homocysteine
- Humans
- Lung Neoplasms
- Methionine
- Mice
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Phenotype
- Rats
- Rats, Inbred Strains
- Rhabdomyosarcoma