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Article

Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia.

Nature communications - 1 Sept 2021

Alfano Massimo, Tascini Anna Sofia, Pederzoli Filippo, Locatelli Irene, Nebuloni Manuela, Giannese Francesca, Garcia-Manteiga Jose Manuel, Tonon Giovanni, Amodio Giada, Gregori Silvia, Agresti Alessandra, Montorsi Francesco, Salonia Andrea

Abstract excerpt

Molecular mechanisms associated with human germ cell aplasia in infertile men remain undefined. Here we perform single-cell transcriptome profiling to highlight differentially expressed genes and pathways in each somatic cell type in testes of men with idiopathic germ cell aplasia. We identify immaturity of Leydig cells, chronic tissue inflammation, fibrosis, and senescence phenotype of the somatic cells, as well...

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Identifiers

PMID: 34471128
DOI: 10.1038/s41467-021-25544-0
PMCID: PMC8410861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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