Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

X‑chromosome loss rescues Sertoli cell maturation and spermatogenesis in Klinefelter syndrome

5 Jun 2024

Abstract excerpt

Klinefelter syndrome (47,XXY) causes infertility with a testicular histology comprising two types of Sertoli cell-only tubules, representing mature and immature-like Sertoli cells, and occasionally focal spermatogenesis. Here, we show that the immature-like Sertoli cells highly expressed XIST and had two X-chromosomes, while the mature Sertoli cells lacked XIST expression and had only one X-chromosome. Sertoli...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38839795
DOI: 10.1038/s41419-024-06792-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

X‑chromosome loss rescues Sertoli cell maturation and spermatogenesis in Klinefelter syndromePMID 38839795Read ↗

<i>Sin3a</i> Is Required by Sertoli Cells to Establish a Niche for Undifferentiated Spermatogonia, Germ Cell Tumors, and Spermatid ElongationSemantic proximity Read ↗

Low <i>XIST</i> expression in Sertoli cells of Klinefelter syndrome patients caused the high susceptibility of these cells to an extra X chromosomeSemantic proximity Read ↗

Focal spermatogenesis originates in euploid germ cells in classical Klinefelter patientsSemantic proximity Read ↗

Unveiling the roles of Sertoli cells lineage differentiation in reproductive development and disorders: a reviewSemantic proximity Read ↗

Sertoli cells as key drivers of testis functionSemantic proximity Read ↗

Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesisSemantic proximity Read ↗

Natural history of seminiferous tubule degeneration in Klinefelter syndromeSemantic proximity Read ↗

A homozygous PIWIL2 frameshift variant affects the formation and maintenance of human induced pluripotent stem cell-derived spermatogonial stem cells and causes Sertoli cell only-syndromeSemantic proximity Read ↗

The X chromosome and male infertility.Semantic proximity Read ↗

Germ cell loss is associated with fading Lin28a expression in a mouse model for Klinefelter's syndromeSemantic proximity Read ↗

Germ cell loss in Klinefelter syndrome: When and why?Semantic proximity Read ↗

Loss of<i>Gata4</i>in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.