Article

Single-cell atlas of human developing and azoospermia patients’ testicles reveals the roadmap and defects in somatic microenvironment

2020-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Non-obstructive azoospermia (NOA) affects 1% of men. However, the unknowns of NOA pathogenesis and even normal spermatogenic microenvironment establishment severely limit the clinical efficacy of NOA treatment. We profiled > 80,000 human testicular single-cell transcriptomes from 10 healthy donors spanning the range from infant to adult and 7 NOA patients. Sertoli cells, which form the scaffold...

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Literature Corpus work: 92f38e54-bedc-5d8f-839f-2f5b00eed2ca
DOI: 10.1101/2020.05.07.082024

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