Article

Progerin-Expressing Endothelial Cells are Unable to Adapt to Shear Stress

2021-08-20

Abstract excerpt

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disease caused by a single-point mutation in the lamin A gene, resulting in a truncated and farnesylated form of lamin A. This mutant lamin A protein, known as progerin, accumulates at the periphery of the nuclear lamina, resulting in both an abnormal nuclear morphology and nuclear stiffening. HGPS patients experience rapid onset of atherosclero...

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Literature Corpus work: 020819bb-eac8-5790-a0ef-8c314c926fb3
DOI: 10.1101/2021.08.20.456996

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