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Article

Single-cell analysis of the progeria arterial wall reveals progerin-induced progressive, cell type-specific dysfunction and somatic mutation accumulation.

Genome medicine - 31 Jul 2026

Merino Lara G, Revêchon Gwladys, Subhash Santhilal, Stefani Fabiana, Whisenant Daniel, Skipitari Marianna, Giraud Quentin, Muhl Lars, Mocci Giuseppe, Björkegren Johan, Machtel Piotr, He Liqun, Betsholtz Christer, Eriksson Maria

Abstract excerpt

BACKGROUND: The premature aging disorder Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by de novo LMNA mutations producing the aberrant Lamin A isoform progerin. HGPS patients die from cardiovascular disease, with their arteries showing extensive cellular and structural remodeling, but the mechanisms driving vascular dysfunction are not fully understood. METHODS: To define molecular processes underlying...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42538566
DOI: 10.1186/s13073-026-01719-6
PMCID: PMC13425876

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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