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Article

Vascular senescence in progeria: role of endothelial dysfunction

1 Jul 2022

Abstract excerpt

Aims: Hutchinson-Gilford progeria syndrome (HGPS) is a pre-mature aging disorder caused by the mutation of the LMNA gene leading to an irreversibly farnesylated lamin A protein: progerin. The major causes of death in HGPS are coronary and arterial occlusive disease. In the murine model of HGPS, vascular smooth muscle cell (VSMC) loss is the primary vascular manifestation, which is different from the arterial...

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PMID: 36117952
DOI: 10.1093/ehjopen/oeac047

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