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iPSC-Derived Endothelial Cells Affect Vascular Function in a Tissue-Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome.

Stem cell reports - 11 Feb 2020

Atchison Leigh, Abutaleb Nadia O, Snyder-Mounts Elizabeth, Gete Yantenew, Ladha Alim, Ribar Thomas, Cao Kan, Truskey George A

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a rare disorder caused by a point mutation in the Lamin A gene that produces the protein progerin. Progerin toxicity leads to accelerated aging and death from cardiovascular disease. To elucidate the effects of progerin on endothelial cells, we prepared tissue-engineered blood vessels (viTEBVs) using induced pluripotent stem cell-derived smooth muscle cells (viSMCs)...

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Identifiers

PMID: 32032552
DOI: 10.1016/j.stemcr.2020.01.005
PMCID: PMC7013250

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