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Article

Shear stress-induced mechanotransduction protein deregulation and vasculopathy in a mouse model of progeria

24 Mar 2014

Abstract excerpt

INTRODUCTION: A mouse model of progeria derived by insertion of the human mutant LMNA gene (mLMNA), producing mutant lamin A, shows loss of smooth muscle cells in the media of the ascending aorta. We hypothesized that high shear stress, in the presence of mutant lamin A, induces this vasculopathy and tried to define the molecular and cellular basis for aortic vasculopathy. METHODS: Ascending and descending aortas...

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PMID: 24661531
DOI: 10.1186/scrt429

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