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Cellular senescence and failure of myelin repair in multiple sclerosis

28 Sept 2020

Abstract excerpt

Remyelination is a physiological response to demyelinating events aiming to restore saltatory conduction and preserve axonal integrity. Resident oligodendrocyte precursor cells (OPC) of the CNS tissue under appropriate conditions are mobilized to proliferate, migrate, and differentiate, in order to produce new myelin sheaths in the demyelinated lesion. In multiple sclerosis (MS), the most common immune-mediated...

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PMID: 32991921
DOI: 10.1016/j.mad.2020.111366

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