Article

TET2 loss promotes premalignant survival and clonal selection in MYC-driven B cell lymphoma

2026-03-21

Abstract excerpt

The DNA demethylase ten-eleven translocation enzyme 2 (TET2) is frequently inactivated in hematologic malignancies, yet how its loss shapes oncogene-driven transformation remains unclear. Using a mouse model in which MYC is overexpressed in the B cell lineage, driving aggressive B cell lymphoma, we show that Tet2 loss increases lymphoma penetrance and biases disease toward an IgM+ immunophenotype. Established lymp...

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Literature Corpus work: 01cc9387-9b3f-501a-8c35-917afcb426a5
DOI: 10.64898/2026.03.20.712678

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