Article

A Chemical Mutagenesis Approach to Insert Post-Translational Modifications in Aggregation-Prone Proteins

2022-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Neurodegenerative diseases are a class of disorders linked to the formation in the nervous system of fibrillar protein aggregates called amyloids. This aggregation process is affected by a variety of post-translational modifications, whose specific mechanisms are not fully understood yet. Emerging chemical mutagenesis technology is currently striving to address the challenge of introducing prote...

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Literature Corpus work: 35c536f6-7924-5fb2-a35b-0d2a7924d3d2
DOI: 10.1101/2022.01.28.478135

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