Back to search

Article

Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer

2024-07-30

Abstract excerpt

<title>Abstract</title> <p>Epigenetic plasticity and large-scale chromatin remodeling characterize tumor evolution and the emergence of subclones resistant to conventional therapies. Catalytically inactive class IIa HDACs (HDAC4, HDAC5, HDAC7, HDAC9) control the targeted recruitment of chromatin remodeling complexes, making them attractive therapeutic targets in oncology. In this study, we found that HDAC4 is pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
01b99417-49eb-56c5-a3fd-f24228056d3c
DOI
10.21203/rs.3.rs-4758082/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Super-enhancers reorganization controls re-sensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancerDOI 10.21203/rs.3.rs-4758082/v1
Class IIa HDACs forced degradation allows resensitization of oxaliplatin-resistant FBXW7-mutated colorectal cancer.Semantic proximity
Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal CancerSemantic proximity
Pharmacological modulation of RB1 activity mitigates resistance to neoadjuvant chemotherapy in locally advanced rectal cancerSemantic proximity
Integrated chromatin and transcriptomic profiling of patient-derived colon cancer organoids identifies personalized drug targets to overcome oxaliplatin resistanceSemantic proximity
Loss of tumour suppressor p53 rewires enhancer landscape and governs oncogenic progressionSemantic proximity
Loss of <i>UBP1</i> drives oxaliplatin resistance through a targetable dependency on translation initiationSemantic proximity
KRAS silencing alters chromatin physical organization and transcriptional activity in colorectal cancer cellsSemantic proximity
Chemical perturbations impacting histone acetylation govern colorectal cancer differentiationSemantic proximity
Landscape of super-enhancers in small cell carcinoma of the ovary, hypercalcemic type and efficacy of targeting with natural product triptolideSemantic proximity
CDK9 degradation Inhibits Gastroesophageal Cancer growth and Overcomes Radiation Resistance by Increasing Chromatin Accessibility and Downregulating YAP1/TEAD signalingSemantic proximity
Competitive antagonism of KAT7 crotonylation against acetylation affects procentriole formation and colorectal tumorigenesisSemantic proximity
Alteration of chromatin high‐order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cellsSemantic proximity
Select a neighboring publication to make it the new centre.