Article

CDK9 degradation Inhibits Gastroesophageal Cancer growth and Overcomes Radiation Resistance by Increasing Chromatin Accessibility and Downregulating YAP1/TEAD signaling

2025-02-27

Abstract excerpt

<h4>Background</h4> Gastroesophageal cancer (GEAC) remains a major health burden and urgently needs novel therapeutic targets. The inhibition of CDK9’s activity holds the potential to be a highly effective anti-cancer therapeutic. However, the functional role of CDK9, and its potential targeting in GEAC, remain largely unknown. <h4>Objective</h4> We aim to evaluate the potential of degradation CDK9 in GEAC treat...

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Literature Corpus work: 1f1d2709-95c2-5d5c-9e58-e39d103b50f8
DOI: 10.1101/2025.02.22.639565

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