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Alteration of chromatin high‐order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cells

29 May 2023

Abstract excerpt

Oxaliplatin is a first-line chemotherapy drug widely adopted in colorectal cancer (CRC) treatment. However, a large proportion of patients tend to become resistant to oxaliplatin, causing chemotherapy to fail. At present, researches on oxaliplatin resistance mainly focus on the genetic and epigenetic alterations during cancer evolution, while the characteristics of high-order three-dimensional (3D) conformation...

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PMID: 37933235
DOI: 10.1002/exp.20220136

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