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Loss of <i>UBP1</i> drives oxaliplatin resistance through a targetable dependency on translation initiation

2026-05-20

Abstract excerpt

Oxaliplatin is a common component of various chemotherapeutic regimens for the treatment of gastrointestinal cancers. However, the majority of patients exhibit resistance to oxaliplatin-based therapy. Here, we integrated knockout and transcription-activation CRISPR screens in patient-derived gastric cancer organoids (GC PDOs) to comprehensively profile major genetic and transcriptomic changes observed over the cou...

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Literature Corpus work
f663ab47-7649-51b5-9e65-16b74c4ca999
DOI
10.64898/2026.05.18.725866
Open publication

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Loss of <i>UBP1</i> drives oxaliplatin resistance through a targetable dependency on translation initiationDOI 10.64898/2026.05.18.725866
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