Article

BAP1 loss impairs Non-Homologous End Joining DNA repair promoting genomic instability

2026-02-18

Abstract excerpt

The tumor suppressor BRCA1-associated protein 1 (BAP1) is frequently mutated in uveal melanoma, where its loss is associated with poor prognosis. Although BAP1 has been implicated in homologous recombination (HR), its role in non-homologous end-joining (NHEJ) remains poorly defined. Here, we show that BAP1 functions as a central regulator of DNA double-strand break (DSB) repair by coordinating HR and NHEJ. BAP1 de...

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Literature Corpus work: 01b19324-f597-5fd5-8016-f2f73c8dcdca
DOI: 10.64898/2026.02.17.706330

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