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Article

53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.

Nature - 1 Aug 2018

Ghezraoui Hind, Oliveira Catarina, Becker Jordan R, Bilham Kirstin, Moralli Daniela, Anzilotti Consuelo, Fischer Roman, Deobagkar-Lele Mukta, Sanchiz-Calvo Maria, Fueyo-Marcos Elena, Bonham Sarah, Kessler Benedikt M, Rottenberg Sven, Cornall Richard J, Green Catherine M, Chapman J Ross

Abstract excerpt

53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination1,2, and reduced fidelity of long-range V(D)J recombination3. The 53BP1-dependent pathway is also responsible for pathological joining events at...

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Share to DNA Breaks, Double-Stranded
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30046110
DOI: 10.1038/s41586-018-0362-1
PMCID: PMC6989217

Genes

SHLD1
SHLD2
SHLD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.PMID 30046110Read ↗

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJSemantic proximity Read ↗

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor SensitivitySemantic proximity Read ↗

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.Semantic proximity Read ↗

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RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signalingSemantic proximity Read ↗

BAP1 loss impairs Non-Homologous End Joining DNA repair promoting genomic instabilitySemantic proximity Read ↗

CHAMP1 binds to REV7/FANCV and promotes homologous recombination repairSemantic proximity Read ↗

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DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis.Semantic proximity Read ↗

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