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Article

An overview of BAP1 biological functions and current therapeutics.

Biochimica et biophysica acta. Reviews on cancer - 1 Apr 2025

Elsayed Abdelrahman M, Kittaneh Muaiad, Cebulla Colleen M, Abdel-Rahman Mohamed H

Abstract excerpt

BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene that was first identified in 1998. Germline loss-of-function variants in BAP1 are associated with a tumor predisposition syndrome with at least four cancers: uveal melanoma (UM), malignant mesothelioma (MMe), renal cell carcinoma (RCC), and cutaneous melanoma (CM). Furthermore, somatic BAP1 mutations are important drivers for several cancers most...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39842618
DOI: 10.1016/j.bbcan.2025.189267
PMCID: PMC12337360

Genes

BAP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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