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Article

Functional Link between BRCA1 and BAP1 through Histone H2A, Heterochromatin and DNA Damage Response.

Current cancer drug targets - 1 Jan 2016

Fukuda Takayo, Tsuruga Tomoko, Kuroda Takako, Nishikawa Hiroyuki, Ohta Tomohiko

Abstract excerpt

BRCA1, a breast and ovarian tumor suppressor, maintains genome stability through its functions in DNA repair, cell-cycle checkpoints, heterochromatin formation and centrosome amplification. BRCA1 interacts with BARD1 to constitute a RING heterodimer-type E3 ubiquitin ligase. BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that also regulates similar cellular events, including cell-cycle control,...

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Topics

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Share to BRCA1 Protein
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Heterochromatin

Share to Molecular Targeted Therapy

Share to Polycomb-Group Proteins

Share to Ubiquitin Thiolesterase

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Source

Identifiers

PMID: 26517537
DOI: 10.2174/1568009615666151030102427

Genes

BRCA1
BAP1
BARD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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