Article
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014
Yu Helen, Pak Helen, Hammond-Martel Ian, Ghram Mehdi, Rodrigue Amélie, Daou Salima, Barbour Haithem, Corbeil Luc, Hébert Josée, Drobetsky Elliot, Masson Jean Yves, Di Noia Javier M, Affar El Bachir
Abstract excerpt
The cellular response to highly genotoxic DNA double-strand breaks (DSBs) involves the exquisite coordination of multiple signaling and repair factors. Here, we conducted a functional RNAi screen and identified BAP1 as a deubiquitinase required for efficient assembly of the homologous recombination (HR) factors BRCA1 and RAD51 at ionizing radiation (IR) -induced foci. BAP1 is a chromatin-associated protein...
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