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Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature

14 Apr 2020

Abstract excerpt

Hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and Alzheimer's disease. Disease-associated mutations in the tau-encoding MAPT gene have enabled the generation of transgenic mouse models that recapitulate aspects of human neurodegenerative diseases, including tau hyperphosphorylation and neurofibrillary tangle formation. Here, we characterized the effects of...

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PMID: 32375177
DOI: 10.1093/brain/awaa133

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